Brain biopsy in Istanbul: Best Clinics and Costs 2024

Neurosurgery Training: Gazi University, Department of Neurosurgery, 2011 H index: 10, I10 Index: 12 Citations: 296 Dr Mehmet Tonge has international and nationwide 32 publications, 12 book chapters, 92 oral and poster presentations and 41 invited lectures, mostly on Stereotactic and Functional Neurosurgery.  Work & Training experience:2004-2011: Gazi University, Department of Neurosurgery (Residency) 2008: Zurich University Hospital, Department of Neurosurgery (Intraoperative MRI applications), Switzerland 2008: Zurich University Hospital, Department of Neurosurgery: Microneurosurgery, white matter dissection, interventional neuroradiology courses, Switzerland 2011 – 2012: Sinop Ataturk State Hospital, Neurosurgeon 2012 – 2013: Cankiri State Hospital, Neurosurgeon 2013 – 2014: Istanbul Medipol University, Department of Neurosurgery & Gamma Knife Center (Ass Prof) 2013 – now: Maastricht University Neurosurgery & Neuroscience Department (Visiting scientist, PhDc) The Netherlands 2014: Maastricht University, The Netherlands: Deep Brain Stimulation Fellowship 2014-2018: Istanbul Memorial Hospital Neurosurgery: Staff Neurosurgeon 2016-2018: Istanbul Florence Nightingale Hospital (Consultant, Gamma Knife Center) 2018-now: Istanbul Medipol University (Stereotactic & Functional Neurosurgery, Gamma Knife Center) Ass. Prof.)  Dr Mehmet Tonge has completed 4-year cycle EANS (European Association of Neurosurgical Societies) Training courses.  Clinical areas of interest: • Stereotactic & Functional Neurosurgery • Surgery for movement disorders* MR Guided Focused Ultrasound (MRgFUS) • Gamma Knife Radiosurgery • Surgery for pain & spasticity • Psychosurgery Research areas of interest: • Deep brain stimulation* MR Guided Focused Ultrasound (MRgFUS) • Stereotactic radiosurgery  Administrative duties: • Turkish Neurosurgical Society, Sterotactic & Functional Neurosurgery Section: Board member 2015- 2017 • Turkish Neurosurgical Society, Sterotactic & Functional Neurosurgery Section: Board member (Secretary) 2017-2019 • Turkish Skull Base Society: Board member 2016-2018 • Turkish Skull Base Society: Supervisory board member 2018-2020 • Deep Brain Stimulation and Movement Disorders Surgery Society: Executive Board Member, (Accountant) 2023-still  Memberships: • WSSFN (World Stereotactic & Functional Neurosurgery Society) • ESSFN (European Stereotactic & Functional Neurosurgery Society) • Deep Brain Stimulation and Movement Disorders Surgery Society • Deep Brain Stimulation Society • International Stereotactic Radiosurgery Society • Leksell Gamma Knife Society • EANS (European Association of Neurosurgical Societies) • Turkish Neurosurgical Society• Turkish Skull Base Society  Sample Publications: 1. Tonge M. Technological developments in electric based DBS. Deep Brain Stimulation 2024 4(36-41) DOI: https://doi.org/10.1016/j.jdbs.2023.12.001 2. Akgul E, Onan HB, Islek I, Tonge M, Durmus Y, Barburoglu M, Azizova A, Erol C, Hakyemez B, Sencer S, Aydin K, Arat A. Flow diverter stents in the treatment of recanalized intracranial aneurysms. Interv Neuroradiol. 2021 Aug;27(4):481-489. doi: 10.1177/1591019921990507. Epub 2021 Jan 28. PMID: 33509011; PMCID: PMC8580529. 3. Mulders AEP, Temel Y, Tonge M, Schaper FLWVJ, van Kranen-Mastenbroek V,Ackermans L, Kubben P, Janssen MLF, Duits A. The association between surgical characteristics and cognitive decline following deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Clin Neurol Neurosurg. 2021 Jan;200:106341. doi: 10.1016/j.clineuro.2020.106341. Epub 2020 Nov 3. PMID: 33160716. 4. Wetzelaer P, Vlis T, Tonge M, Ackermans L, Kubben P, Evers S, Kocabicak E, Temel Y. Management of Hardware Related Infections after DBS Surgery: A Cost Analysis. Turk Neurosurg. 2018;28(6):929- 933. doi: 10.5137/1019-5149.JTN.21511-17.1. PMID: 29465741. 5. Bedirli N, Emmez G, Ünal Y, Tönge M, Emmez H. Effects of positive end- expiratory pressure on intracranial pressure during pneumoperitoneum and Trendelenburg position in a porcine mode. Turk J Med Sci. 2017 Nov 13;47(5):1610-1615. doi: 10.3906/sag-1609-17. PMID: 29152942. 6. Sari R, Tonge M, Bolukbasi FH, Onoz M, Baskan O, Silav G, Elmaci I. Management of Failed Cranioplasty. Turk Neurosurg. 2017;27(2):201-207. doi: 10.5137/1019-5149.JTN.15395-15.0. PMID: 27593759. 7. Tonge M, Kocabicak E, Ackermans L, Kuijf M, Temel Y. Final Electrode Position in Subthalamic Nucleus Deep Brain Stimulation Surgery: A Comparison of Indirect and Direct Targeting Methods. Turk Neurosurg. 2016;26(6):900-903. doi: 10.5137/1019-5149.JTN.13739-14.1. PMID: 27337232. 8. Tonge M, Ackermans L, Kocabicak E, van Kranen-Mastenbroek V, Kuijf M, Oosterloo M, Kubben P, Temel Y. A detailed analysis of intracerebral hemorrhages in DBS surgeries. Clin Neurol Neurosurg. 2015 Dec;139:183-7. doi: 10.1016/j.clineuro.2015.10.017. Epub 2015 Oct 23. PMID: 26513430. 9. Silav G, Bölükbaşı FH, Özek E, Tönge M, Önöz M, Elmacı İ. A Simple Technique for Bone Storage after Decompressive Craniectomy in Children. Pediatr Neurosurg. 2015;50(3):161-4. doi: 10.1159/000381748. Epub 2015 May 14. PMID: 25998533. 10. Yilmaz MB, Donmez H, Tonge M, Senol S, Tekiner A. Vertebrojugular arteriovenous fistula and pseudoaneurysm formation due to penetrating vertebral artery injury: case report and review of the literature. Turk Neurosurg. 2015;25(1):141-5. doi: 10.5137/1019-5149.JTN.8247-13.1. PMID: 25640560. 11. Kurt G, Tönge M, Çeltıkçı E, Çapraz I, Serdaroğlu A, Bılır E. Surgery for intractable temporal lobe epilepsy: experience of a single institution. Turk J Med Sci. 2014;44(5):866-70. doi: 10.3906/sag-1307- 30. PMID: 25539559. 12. Yılmaz MB, Tönge M, Emmez H, Kaymaz F, Kaymaz M. Neuroprotective effects of quetiapine on neuronal apoptosis following experimental transient focal cerebral ischemia in rats. J Korean Neurosurg Soc. 2013 Jul;54(1):1-7. doi: 10.3340/jkns.2013.54.1.1. Epub 2013 Jul 31. PMID: 24044072; PMCID: PMC3772279. 13. Yilmaz MB, Egemen E, Tonge M, Kaymaz M. Transoral protrusion of a peritoneal catheter due to gastric perforation 10 years after a ventriculoperitoneal shunting: case report and review of the literature. Turk Neurosurg. 2013;23(2):285-8. doi: 10.5137/1019-5149.JTN.4904-11.1. PMID: 23546921. 14. Omerhodzic I, Tonge M, Matos B, Musabeliu E, Raspanti C, Ferdinandov D, Galimova R, Muroi C, Balik V, Kursumovic A. Neurosurgical training programme in selected European countries: from the young neurosurgeons' point of view. Turk Neurosurg. 2012;22(3):286-93. doi: 10.5137/1019- 5149.JTN.5133-11.0. PMID: 22664994. 15. Ergun E, Kurt G, Tonge M, Aytar H, Tas M, Baykaner K, Ceviker N. Effects of phenytoin sodium on dura mater healing in a rat model of CSF leakage. Turk Neurosurg. 2011;21(4):471-6. PMID: 22194102. 16. Emmez H, Tonge M, Tokgoz N, Durdag E, Gonul I, Cevıker N. Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety. Turk Neurosurg. 2010 Oct;20(4):485-91. doi: 10.5137/1019- 5149.JTN.3300-10.2. PMID: 20963698. 17. Emmez H, Yildirim Z, Kale A, Tönge M, Durdağ E, Börcek AO, Uçankuş LN, Doğulu F, Kiliç N, Baykaner MK. Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemiareperfusion injury in rabbits. Acta Neurochir (Wien). 2010 Sep;152(9):1591-600; discussion 1600-1. doi: 10.1007/s00701-010-0703-9. Epub 2010 Jun 10. PMID: 20535507. 18. Kurt G, Tonge M, Börcek AO, Karahacioglu E, Gurel O, Baykaner K, Ceviker N, Aykol S. Fractionated gamma knife radiosurgery for optic nerve tumors: a technical report. Turk Neurosurg. 2010 Apr;20(2):241-6. doi: 10.5137/1019-5149.JTN.1681-09.3. PMID: 20401852. 19. Emmez H, Kale A, Tönge M, Cakir A, Ceviker N. Two meningiomas with different histological grades in the same patient. Case report. Neurol Med Chir (Tokyo). 2010;50(8):686-8. doi: 10.2176/nmc.50.686. PMID: 20805656.

Education and Expertise1998 - 2005 - Marmara University Faculty of Medicine1998 - 2005 - Marmara University, Faculty of Medicine, Department of Neurosurgery, Istanbul(Head of the Department: Prof Dr Türker KILIÇ)2011 - 2012 - Yale School of Medicine, New Haven, CT, USA (Director: Murat Günel MD. PhD., Professor of Neurosurgery)Cerebrovascular Research Fellowship Professional Memberships2014 + Turkish Neurosurgery Association2017 + Turkish Spine Association2018 + AOSpine AwardsTurkish Neurosurgery Society 31st Scientific Congress “Prof. Dr. Hamit Ziya Gökalp Young Neurosurgeon Encouragement First Prize”, Antalya, 2017. Courses and Certificates1. Member of the Organizing Committee; 12. National Neuroscience Congress, Bahçeşehir University, 28-31 May 20142. Member of the Organizing Committee; 11. ASNO 'Skull-base Anatomy Course', 11-14 September 2014, Istanbul3. Instructor / Member of the Organizing Committee; Neurosurgery Course Series – 4 /Prof. Dr. Evandro de Oliveira Skull Base Course 2, Prof. Rhoton Anatomy Lab BAU Faculty of Medicine, Istanbul, 2015.4. Member of the Organizing Committee; International Deep Brain Stimulation Surgery Microelectrode Recording Cadaver Course, Rhoton Anatomy Lab BAU Faculty of Medicine, 6-7 February 2015 Istanbul.5. Organization Officer; TND Istanbul Meetings, Istanbul, 2015-2016

2002-2007 Istanbul University Istanbul Faculty of Medicine Department of Brain and Nerve Surgery1988-1995 Trakya University Faculty of Medicine 2015- Atlas University Medicine Hospital2014-2015 Private Pendik Yüzyıl Hospital Brain and Neurosurgery Clinic2009-2014 Medicine Hospital Brain and Neurosurgery Clinic2009-2009 Nisa Hospital Brain and Neurosurgery Clinic2007-2009 Mardin State Hospital Brain and Neurosurgery Clinic2002-2007 Istanbul University Istanbul Faculty of Medicine Brain and Neurosurgery1997-2001 Enez Health Center and Enez State Hospital Cervical, Thoracic and Lumbar Disc Surgery (endoscopic/microsurgery)Far lateral (non-canal) lumbar disc surgery (lateral microsurgical approach)Neurovascular surgeryCerebrovascular diseases (vascular diseases of the brain)AneurysmsArteriovenous malformationsCavernomasNeuro-oncological surgeryBrain tumorsGlial tumorsMeningiomasPituitary gland tumorsMetastatic brain tumorsSkull base tumorsPontocerebellar angle tumorsPineal tumorsIntraventricular tumorsSpinal disease surgeryCervical, thoracic and lumbar spine fracturesSpine and spinal cord tumorsScoliosisDegenerative spine diseasesPeripheral nerve disease surgeryPeripheral nerve tumorsEntrapment neuropathiesCarpal tunnel syndromeUlnar groove syndromeTarsal tunnel syndromeFunctional neurosurgery and pain surgeryTrigeminal neuralgiaMicrovascular decompressionEpilepsy surgerySpasticity surgeryEpiduroscopic interventionsHydrocephalus surgeriesEndoscopic 3rd ventriculostomyVP shunt surgeriesLP shunt surgeriesDevelopmental anomaliesMeningomyeloceleTethered cord syndromeArachnoid cystCraniosynostosis surgeriesChiari malformationHead traumaSubdural hematomasIntracerebral hematomas Article published in internationally refereed journalsCansever T, Civelek E, Sencer A, Karasu A, Kiris T, Hepgül K, Can H, Canbolat A: Spinal cavernous malformations: a report of 5 cases. Surg Neurol Jun 69 Effects of combined and individual use of N-methyl-D aspartate receptor antagonist magnesium sulphate and caspase-9 inhibitor z-LEDH-fmk experimental spinal cord injury. A.Sencer, A.Aydoseli, Y.Aras, M.Osman Akçakaya, C.Gömleksiz, H.Can, A.Canbolat. Turkısh Joumal of Trauma&Emergency Surgery 2013Aydoseli A, Can H, Aras Y, Sabanci PA, Akcakaya MO, Unal OF. Memantine and Q-VD-OPh Treatments in Experimental Spinal Cord Injury: Combined Inhibition of Necrosis and Apoptosis. Turk Neurosurg. 2016Can H, Kircelli A, Kavadar G, Civelek E, Cansever T, Aydoseli A, Onal MB, Yilmaz C. Lumbosacral Conjoined Root Anomaly: Anatomical Considerations of Exiting Angles and Root Thickness. Turk Neurosurg. 2017Kırcelli A, Özel Ö, Can H, Sarı R, Cansever T, Elmacı İ. Is the presence of linear fracture a predictor of delayed posterior fossa epidural hematoma? Ulus Travma Acil Cerrahi Derg. 2016 JulKavadar G, Demircioğlu DT, Can H, Emre TY, Civelek E, Senyigit A. The clinical factors associated with benefit finding of complementary medicine use in patients with back pain: A cross-sectional study with cluster analysis. J Back Musculoskelet Rehabil. 2017Ozer AF, Suzer T, Can H, Falsafi M, Aydin M, Sasani M, Oktenoglu T. Anatomic Assessment of Variations in Kambin’s Triangle: A Surgical and Cadaver Study. World Neurosurg. 2017 AprCan H, Aydoseli A, Gömleksiz C, Göker B, Altunrende ME, Dolgun M, Sencer A. Combined and individual use of pancaspase inhibitor Q-VD-OPh and NMDA receptor antagonist riluzole in experimental spinal cord injury. Ulus Travma Acil Cerrahi Derg. 2017Gomleksiz C, Erbulut DU, Can H, Kodigudla MK, Kelkar AV, Kasapoglu E, Ozer AF, Goel VK. A new lumbar fixation device alternative to pedicle-based stabilization for lumbar spine: In vitro cadaver investigation. J Spinal Cord Med. 2018 Jul 16:1-8.Aydoseli A, Özgen U, Akgül T, Orhan EK, Adıyaman AE, Can H, Karadağ C. Subacute Traumatic Ascending Myelopathy in a 28-year-old man: A rare case. World Neurosurg. 2019 Apr 28 Article published in national refereed journals1) Intracranial Hemangioblastomas: Clinical Evaluation of 32 Patients T. Cansever, A. Karasu, K. Hepgül, H. Can, A. Sencer Turkish Neurosurgical Journal 2007, Volume:17 2) Halil Can, Müge Dolgun, Utku Özgen, Cengiz Gömleksiz, Furkan Diren, Aydın Aydoseli, Yavuz Aras, Altay Sencer. Microsurgical Results in Vestibular Schwannoma Patients; Retrospective Clinical Study. JAREM 20193) Furkan Diren , Özcan Gayretli , Halil Can , İlke Ali Gürses , Orhan Barlas. Examination of Pons-Cerebellum Cisterna Anatomy with Endoscopic Retrosigmoid Suboccipital Approach: Cadaver Study. JAREM 2019