Treatment in Milan (Italy)

Prof. Luca Balzarini is the head of the Department of Diagnostic Imaging in Humanitas Research Hospital. He lectured at the post-graduation school in Radiology at the University of Milan and Pavia and he is member of the European Society of Radiology and of the Italian Society of Medical Radiology (SIRM).
He graduated cum laude in Medicine and Surgery at the University of Milan in 1982 and in 1986 he graduated cum laude at the post-graduation school of Radiology at the University of Milan.

His career started at Istituto Nazionale dei Tumori in Milano where he attended as a PHD student of the University of Milan.
After a long experience abroad, where he developed master expertise in Magnetic Resonance Imaging, he then became Assistant in the Department of Diagnostic radiology at Istituto Nazionale dei Tumori (IRCCS) in Milan where he has this role for 12 years now.

Since 1997 he has been working at Humanitas Research Hospital as head of Magnetic Resonance Section, and then head of Diagnostic Radiology Unit (2006). Nin 2012 he became head of Department of Diagnostic Imaging.

In his high technology Department there are 5 MRI machines (from 1 up to 3 T units), 4 CT scans, and an angiography suite, all radiological techniques are regulated by a system of dose control (Dose Watch).

His team, composed of 25 radiologists, has recognized expertise in several fields of Diagnostic and Interventional Imaging and particularly dedicated in Oncological, Muscle-Skeletal, Neuro and Cardiac Imaging.

Prof. Giorgio Walter Canonica is the Head of Personalized Medicine Center: Asthma and Allergy in Humanitas Research Hospital.

Medical areas of interest:
Asthma and allergies 

Research areas of interest: 
T cells: study of different subgroups and their functional role in basic and clinical research (allergy, specific autoimmunity of organs, degenerative diseases of the CNS and cancer).

Molecular events and interactions between immunocompetent cells, inflammatory cells, epithelial cells in allergic inflammation and airway remodelling.

Biomarkers that define the therapeutic response in asthma.

New antiallergenic drugs and new strategies in the treatment of allergic disease.

Clinical and immune-pharmacological activities of modifiers of biological responses such as cytokines, monoclonal antibodies, specific immunotherapy for allergens, etc.

Results of reported patients and assessment of quality of life in patients with respiratory and allergic diseases.

Prof. Canonica coordinated and conducted more than 50 tests (phase II-IV) according to current GCP rules (certification number 2426574, 29/06/2017).

He has also served as an arbitrator for most of the most important international journals - Editor-in-Chief of "Current Opinion in Allergy and Clinical Immunology" – Associated Editor "Annals of Allergy & Clinical Immunology".

Previous experience:
Director of the Degree programme of Lung Diseases at the University of Genoa (1998 - Today) President of the Clinic for Diseases of Allergies and Respiratory - Department of Internal Medicine, University of Genoa - IRCCS AOU San Martino IST

(1997) Director of the Specialized School of Allergy and Clinical Immunology DIMI, University of Genoa

• (1998-present) Full professor of allergies and respiratory diseases, Department of Internal Medicine, University of Genoa
   
• (1995-1998) Full professor of Internal Medicine, Department of Internal Medicine, University of Genoa
   
• (1982) Associate Professor Allergy and Clinical Immunology-Dept. of Internal Medicine
  (1977) Assistant Professor of Internal Medicine - University of Genoa
• (1973) Assistant at the Clinic of Pulmonary Diseases - University of Genoa

Publications:

https://www.ncbi.nlm.nih.gov/pubmed/?term=giorgio+walter+canonica

Dr. Lorenzo Di Mento is the Head of the Traumatology Unit in Humanitas Research Hospital. He is also part of the council of AO Trauma Italy with the role of Community Development. 

He specialized in Orthopaedics and Traumatology at the University of Milan (2000-2005), completing several internships abroad:

• 2003 Marseille (France), Centre Phocea, Dr. Bronsard, vertebral surgery
• 2003 Marseille (France), Hopital Nord, Dr. Poitout, traumatology
• 2003-2004 Basse Terre (Guadeloupe), Centro Ospedaliero de la Basse Terre (CHBT), dr Fleurat, acting as intern (equivalent of the French specializing)

He also completed a Fellowship of AO Trauma International at the Centre Hospitalier Universitaire Vadois (CHUV) in Lausanne (Switzerland) in 2016, at the center of pelvic surgery and treatment of septic complications in orthopedics and traumatology, directed by Dr. Borens.

He surgically treats fractures, both acutely ongoing ones (with intervention of reduction and synthesis as soon as possible, in accordance with soft tissues and the patient’s conditions) and as psthumous traumas (pseudoarthrosis, bad or non consolidation). He handles polyfractured and polytrauma patients. Dr. Di Mento also treats infections in a traumatic environment, such as septic psedutoarthrosis and surgically the minor tumoral bone localizations, such as osteolysis, impending fractures and pathological fractures. 

Publications: https://pubmed.ncbi.nlm.nih.gov/?term=Di+Mento+L 

Prof. Marco Klinger is director of the School of Specialization in Plastic, Reconstructive and Aesthetic Surgery at the University of Milan and Head of the Operating Unit in Plastic, Reconstructive and Aesthetic Surgery at Humanitas Research Hospital.

He specializes in plastic and reconstructive surgery: treatment of scars, burns, outcomes of bariatric surgery, regenerative medicine and surgery, post-oncological breast reconstruction, breast malformations and skin oncology. Aesthetic plastic surgery: augmentation mammoplasty, mastopexy, reduction mammoplasty, rhinoplasty/ rhinoseptoplasty, lifting, liposuction, abdominoplasty, blepharoplasty and otoplasty.

Research interests: Regenerative medicine and surgery.

Prof. Klinger and his team have performed more than 35,000 plastic surgery and reconstructive surgery; he is the author of over 200 scientific articles, published in national and international journals. Among his most recent and significant studies, the use of lipofilling in treatment of severe burn outcome, scleroderma and chronic pain syndromes, such as Post Mastectomy Pain Syndrome.

Scientific publications: 

http://www.ncbi.nlm.nih.gov/pubmed?term=klinger%20marco

Dr. Bernhard Reimers – Clinical and Invasive Cardiology Unit Director in Humanitas Research Hospital, was born in Germany. He graduated in medicine and surgery in University of Padua (Italy) in 1990, followed by specialization in Cardiology. During the first 3 years of specialization in Cardiology in the Coronary Unit of Padua University, his particular interests were in managing cardiovascular urgency and critical patients, including management of fans, balloon pump, hemofiltration, temporary pacing, placement of central venous pathways and Swan-Ganz catheter. He spent his last year of specialization at the Hemodynamics of Casa di Cura Columbus (Milan), where he acquired his knowledge on the main diagnostic techniques he uses. After a short period of study at the Thoraxcenter of Rotterdam, during which he wrote his first scientific publications, Dr. Reimers has dedicated himself to hemodynamics and cardiovascular surgeries, working as Unit Director main assistant, executing angioplasty, coronary and peripheral procedures, reaching complete autonomy in coronary stenting, atherectomy, ultrasound intravascular and intracoronary doppler.

Since September 1997 he has managed and developed the diagnostic and interventional cardiovascular program at the Department of Cardiology of Mirano (Venice), where, thanks to his achievements, since 2000 the highest number of coronary angioplasties were performed. In 2006 the Unit has performed 975 coronary angioplasties (including 125 primary), more than 400 carotid angioplasty and peripherals. Dr. Reimers became Unit Director and has trained and taught a young team of interventional cardiologists, including 4 completely independent in the performance of coronary angioplasty, which manages both hemodynamics and largely the CCU in close collaboration between the two services. After this important experience, he was invited to be part of Humanitas Research Hospital as Clinical and Invasive Cardiology Unit Director.

Dr. Reimers participates in many scientific studies on the treatment of myocardial infarction considering new interventional or pharmaceutical approaches for primary angioplasty. He was also member of the Technical Commission of the Regional Bid for the purchase of stents. Thanks to Dr. Reimers’ efforts, Hemodynamics of Mirano (Venice) is considered reference center for primary angioplasty and elective complex procedures. Dr. Reimers is considered to be one of the leading experts of carotid angioplasty worldwide. He is preparing a program for interventional treatment of acute stroke. He performs routine renal angioplasty and implants percutaneous devices and endoprosthesis systems for aortic aneurysms.

Dr. Reimers has published, as author or co-author, 77 articles quoted in Medline. The impact factor calculated based on 2006 is 263. He published 9 book chapters and several abstracts for important international conferences dedicated to Cardiology, such as TCT, PCR, National GISE ANMCO, JIM and ESC, were he also performed live invasive procedures.

Dr. Reimers has always considered participation in clinical trials and scientific international events among the main activities of his professional carrier. Besides teaching at University of Tor Vergata in Rome, he organizes many conferences, national and international medical follow-up courses. For over 9 years he has been organizing theoretical and practical courses with lectures and transmission of live procedures in Venice. He has so far organized two editions of TOBI, international meeting dedicated to invasive treatment of total coronary occlusions and bifurcations, three editions of ETI, international conference and the largest in Italy, dedicated to invasive cardiology devices. 

Dr. Reimers was member of the scientific committee in the editions of 2006 and 2007 of National Convention GISE (Italian Group of Hemodynamic Study) and participated at important events dedicated to CAPTURE study, ESIRIUS, SYNTAX, TIMI 38, FINESSE and many others.

Publications: ttp://www.ncbi.nlm.nih.gov/pubmed/?term=bernhard

Prof. Andrea Lania has graduated at the Università degli Studi of Milan and is specialized in endocrinology. He is the Unit Director of Endocrinology and Diabetology in Humanitas Research Hospital and his specialization is pituitary diseases, pituitary adenomas, thyroid cancer, pancreatic neuroendocrine tumors, poorly differentiated neuroendocrine carcinomas.

Medical areas of interest:
Pituitary tumors, hypopituitarism, acromegaly, Cushing’s disease and syndrome, neuroendocrine tumors, thyroid and thyroid diseases, adrenal and adrenal diseases, hypogonadism.

Research areas of interest:
Study of the pathogenetic mechanisms of pituitary and neuroendocrine tumors, of the molecular mechanisms responsible for the different response of pituitary and neuroendocrine tumors to medical therapy.

Prof. Lania published 198 peer-reviewed papers (Google Scholar H-Index 47; Scopus H-Index 38, cit tot 4604)

Prof. Lania has a long standing expertise in the field of intra-cellular signaling in endocrine tumors. In particular, in the past ten years, he contributed to analyze the role of PKA regulatory subunits in the pathogenesis and control of cell proliferation of endocrine tumors. Moreover, he contributed to define the role of SSTR5 domains involved in the intracellular trafficking of this receptor in human pituitary cells and to analyze the impact of DR2R and SSTR2&5 polymorphic variants on both the clinical outcome and response to medical treatment in patients with pituitary tumors.

Recently, he contributed to identify the role of cytoskeleton protein FLNA in mediating both intracellular signaling and membrane targeting of somatostatin type 2 receptor and D2R in pituitary and pancreatic neuroendocrine tumors. Finally, he contributed to explore the intracellular mechanisms possibly involved in mediating the interplay between drugs commonly used in the treatment of neuroendocrine tumors.

Previous experience:
2005-2008 Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
Director of Endocrinologic Day Hospital and surgery on pituitary disorders. 

Publications: https://www.ncbi.nlm.nih.gov/pubmed?term=lania%20A 

Dr. Corrado Lodigiani has been assistant at the Thrombosis Centre of Humanitas research Hospital from 1998 to 2013 and he became Unit Director in 2013. 

Humanitas Thrombosis Center is a state-of-the-art service for the proper management of the diagnosis and therapy of venous thromboembolic pathology (deep and superficial venous thrombosis, pulmonary thromboembolism, visceral venous thrombosis) and arterial (myocardial infarction, cerebral stroke, peripheral arterial disease). 
Other also rare diseases treated are atypical thrombosis, such as the vascular circulation of the retina, the hearing system and the placental circulation during pregnancy. 

Dr. Lodigiani adopts the multidisciplinary approach and works in collaboration with all medical and surgical specialties. In particular, he carries out clinical and instrumental diagnostics (vascular ecocolordoppler) and research on the causes, diagnosis and therapy of thrombotic and bleeding disorders, congenital and acquired. His clinical activity also involves the diagnosis and management of patients suffering from bleeding diseases, such as haemophilia, von Willebrand’s disease and platelet diseases.

Medical areas of interest:  

In recent years, he has devoted himself with particular interest to the testing, in the role of Principal Investigator in International Clinical Studies, of new antithrombotic drugs and, above all, anticoagulants, which are about to be marketed and will constitute a valid and safe alternative to traditional oral anticoagulant therapy (DOACs). He is also working, with great interest, on researching the causes of idiopathic in and the usefulness and effectiveness of some therapeutic strategies, such as the use of anticoagulant drugs, improving the results of artificial insemination procedures. He is the author of numerous articles in international scientific journals and speaker at numerous national and international conferences.