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Prof. Giorgio Walter Canonica is the Head of Personalized Medicine Center: Asthma and Allergy in Humanitas Research Hospital.

Medical areas of interest:
Asthma and allergies 

Research areas of interest: 
T cells: study of different subgroups and their functional role in basic and clinical research (allergy, specific autoimmunity of organs, degenerative diseases of the CNS and cancer).

Molecular events and interactions between immunocompetent cells, inflammatory cells, epithelial cells in allergic inflammation and airway remodelling.

Biomarkers that define the therapeutic response in asthma.

New antiallergenic drugs and new strategies in the treatment of allergic disease.

Clinical and immune-pharmacological activities of modifiers of biological responses such as cytokines, monoclonal antibodies, specific immunotherapy for allergens, etc.

Results of reported patients and assessment of quality of life in patients with respiratory and allergic diseases.

Prof. Canonica coordinated and conducted more than 50 tests (phase II-IV) according to current GCP rules (certification number 2426574, 29/06/2017).

He has also served as an arbitrator for most of the most important international journals - Editor-in-Chief of "Current Opinion in Allergy and Clinical Immunology" – Associated Editor "Annals of Allergy & Clinical Immunology".

Previous experience:
Director of the Degree programme of Lung Diseases at the University of Genoa (1998 - Today) President of the Clinic for Diseases of Allergies and Respiratory - Department of Internal Medicine, University of Genoa - IRCCS AOU San Martino IST

(1997) Director of the Specialized School of Allergy and Clinical Immunology DIMI, University of Genoa

• (1998-present) Full professor of allergies and respiratory diseases, Department of Internal Medicine, University of Genoa
   
• (1995-1998) Full professor of Internal Medicine, Department of Internal Medicine, University of Genoa
   
• (1982) Associate Professor Allergy and Clinical Immunology-Dept. of Internal Medicine
  (1977) Assistant Professor of Internal Medicine - University of Genoa
• (1973) Assistant at the Clinic of Pulmonary Diseases - University of Genoa

Publications:

https://www.ncbi.nlm.nih.gov/pubmed/?term=giorgio+walter+canonica

Dott. Federico Della Rocca is the Prosthetic and Minimally Invasive Hip and Knee Orthopaedics. 

Medical areas of interest: 
Pathology of the hip and knee, with particular interest in prosthetic and arthroscopic hip surgery. He performs about 700 surgeries every year. He has numerous participations as speaker at national and international conferences.

Previous experience:
He was an attending physician at Steadman Hawkins Clinic Hospital, Vail Colorado, USA. 

He gave a great contribution to the development of the GTS (Global Tissue Sparing) hip prosthetic stem and biomechanical rotational stability tests with Prof Thomsen, Heidelberg (Germany) 12/2012.

Research areas of interest: 
Arthroscopic techniques on the hip

Teaching experience: 
Theory and practical courses in arthroscopic and prosthetic hip surgery at Medical Education

Prof. Luca Balzarini is the head of the Department of Diagnostic Imaging in Humanitas Research Hospital. He lectured at the post-graduation school in Radiology at the University of Milan and Pavia and he is member of the European Society of Radiology and of the Italian Society of Medical Radiology (SIRM).
He graduated cum laude in Medicine and Surgery at the University of Milan in 1982 and in 1986 he graduated cum laude at the post-graduation school of Radiology at the University of Milan.

His career started at Istituto Nazionale dei Tumori in Milano where he attended as a PHD student of the University of Milan.
After a long experience abroad, where he developed master expertise in Magnetic Resonance Imaging, he then became Assistant in the Department of Diagnostic radiology at Istituto Nazionale dei Tumori (IRCCS) in Milan where he has this role for 12 years now.

Since 1997 he has been working at Humanitas Research Hospital as head of Magnetic Resonance Section, and then head of Diagnostic Radiology Unit (2006). Nin 2012 he became head of Department of Diagnostic Imaging.

In his high technology Department there are 5 MRI machines (from 1 up to 3 T units), 4 CT scans, and an angiography suite, all radiological techniques are regulated by a system of dose control (Dose Watch).

His team, composed of 25 radiologists, has recognized expertise in several fields of Diagnostic and Interventional Imaging and particularly dedicated in Oncological, Muscle-Skeletal, Neuro and Cardiac Imaging.

Prof. Marco Alloisio is the thoracic surgery Unit Director at Humanitas Research Hospital. He graduated in Medicine in 1976 at Università Statale of Milan, specialized in General Surgery, Oncological and Thoracic Surgery. 

Under the guidance of Professor Umberto Veronesi, from 1977 to 1997 he was an assistant in the divisions of general oncological, otolaryngology and thoracic surgery at the National Cancer Institute of Milan (INT). During this period, he also worked with general surgery, breast surgery, oncological otorhinolaryngology and had several periods spent studying abroad (Paris and New York at the Memorial Sloan Kettering Cancer Center).

In 1997 he started his activity at Humanitas Research Hospital and in 1998 he was appointed Chief of Mini-Invasive Thoracic Surgery. From 2006 he was designated Chief of Thoracic Surgery at the same Institution. Main clinical activity has been focused on Thoracic Surgical Oncology, and in particular all kinds of surgical management of primary and secondary lung cancer, lung metastases, mediastinal tumors and thoracic wall tumors. Prof. Marco Alloisio is president of the Italian League for the fight against cancer (LILT) in Milan, and member of many national and international societies (SIC, SICO, ESSO, ISDE, ACOI, SICT, ESTS).

Author of over 200 publications, including articles and presentations to national and internationals scientific meetings. His engagement in clinical research involves early detection and management of primary lung cancer and his treatment also with video-assisted techniques, successful treatment of lung metastases with new techniques for salvage surgery (multiple sub lobar resections and laser resections) but also aggressive surgery for advanced lung cancers after induction chemotherapy and treatment of the thoracic wall and vertebral bodies. 
In the latter field, he is engaged in the surgical treatment of malignant pleural mesothelioma (extra pleural pneumonectomy) with multimodality approaches in a multicentric Italian cooperative group.

Currently engaged in genetic research studies such as "ERCC1 and B-Tubulin exspression in locally advanced NSCLC treated with platinum/vinorelbin neodjuvant chemotherapy" and in external collaborations with universities and hospitals around the world.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=alloisio+marco

Prof.  Marco Francone is the Cardiovascular Imaging Unit Director in Humanitas Research Hospital.

Medical areas of interest:

Imaging in cardiovascular and pulmonary diseases

Previous experience:

- First level Medical Director at the Department of Radiological, Oncological and Anatomy-Pathological Sciences, at Policlinico Umberto I in Rome

- Past-President, Cardiology Section at the Italian Society of Medical Radiology (SIRM)

Research areas of interest: 

Inflammatory heart disease, cardiomyopathy, imaging of acute myocardial infarction, imaging in cardio-toxicity, imaging of post-COVID patients.

Prof.  Marco Francone is the author of more than 150 indexed scientific papers with an impact factor of more than 500 and has lectured around the world for fifteen years, from the United States to Asia, from Africa to Australia.

Teaching experience:

Full Professor of Radio diagnostics at Humanitas University

Publications:

https://pubmed.ncbi.nlm.nih.gov/?term=marco+francone&sort=pubdate&size=200&show_snippets=off

Dr. Marco Grimaldi is the Diagnostic Neuroradiology Unit Director in Humanitas Research Hospital.

Medical areas of interest:

• magnetic resonance
• computed tomography
• angiography of the central nervous system, brain and spine
• study of the brachial plexus
• functional neuroradiology, in particular, study of cerebral perfusion for perfusion CT related to problems in an emergency regime
• spine dimorphism, in particular of the paediatric age and in rare diseases

He has developed full diagnostic, organizational and managerial autonomy of any problem in outpatient, hospital and emergency neuroradiology.

Research areas of interest:

• Functional imaging studies on coma
• Diagnosis and development of prognostic algorithms
• Research and development, even experimental, of new applications related to technological developments (research on new protocols for the use of the Multidetector Computed Tomography (MDCT), for the use of perfusion CT in vascular and emergency environments finally, study of the trachea in patients at risk of anesthesiology).

Previous experience:

1990 – 2012 Neuroradiologist at Hospital of San Gerardo in Monza, Italy

He was the Director on highly specialised activities related to functional neuroradiology. 

He worked in diagnostic autonomy, organization and management of any problem within neuroradiological outpatient, inpatient and emergency context. 

He is particularly interested in the field of functional neuroradiology, in research and experimental development of new applications also tied to technological developments and creation of new protocols for use of MDCT (use of CT perfusion imaging in the field of vascular and urgency. He was involved in the study of the trachea in patients at high anaesthetic risk), in paediatric radiology with particular reference to diagnosis and clinical management of rare diseases (consultant in the Outpatient Unit for metabolic diseases and in the Outpatient Unit for rare and genetic diseases at the Hospital). He is also interested in the study of problems related to the craniocervical junction.

Teaching experience: 

From 2002 to 2012 he has been a professor at Milano-Bicocca University of Milan.

From 2002 to 2012 : Professor of the courses "Technique and diagnostics for images I", "Technique and diagnostics for images II" and "Semeiotics neuroradiological CT" for the degree in Medical Radiology for Images and Radiotherapy.
From 2003 to 2012: Professor of the course "Functional Brain Diagnostics" for the Degree in Physiotherapy. 
From 2003 to 2012: Professor for the Degree Course in Neurotherapy and psychomotricity of the developmental age.
From 2006 to 2009: Lecturer at the School of Specialization in Radiodiagnostics.

Prof. Dr. Maria Grazia Bordoni is the Vascular Surgery Unit Director in Humanitas Research Hospital. She has graduated at Università degli Studi of Milan and specialised as a vascular surgeon and since then she has been interested in vascular surgery in all its aspects.

Medical areas of interest:

Her main specialties are endovascular surgery and treatment of the large vessels of the abdomen and thorax (aorta, thoracic cavity), carotid surgery, endovascular and surgical treatments for arteries of the lower limbs, preparation of complex vascular access in hemodialysis, phlebology, diagnosis and treatment of vascular malformations. 

Research areas of interest: 

When it comes to the research activity, Dr. Bordoni is mainly dealing with early treatment of acute ischemic strokes and stimulation of the carotid baroreceptors in patients with heart failure. Prof. Bordoni has performed more than 2000 surgeries as first surgeon in her Humanitas career. 

Since 2005, she is also Milan University professor: she teaches General Surgery and focuses on the topic of vascular and surgical emergencies.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=bordoni+mg

Prof. Guido Grappiolo is Orthopedics Hip and Prosthesis Unit Director in Humanitas Research Hospital. Since 1991, Prof. Guido Grappiolo began working as a researcher dedicated mainly to hip surgery in cooperation with internationally renowned authors such as: Prof. Ganz Prof. T. Gruen, Prof. D. Blaha (U.S.A.), Prof. H. Wagner (Germany), Prof. E. Morscher (Switzerland).

He collaborates with major international schools in the research of new and modern strategies in the field of minimally invasive prosthetics, computer-assisted surgery and conservative surgery. To encourage research in orthopedics is the main scientific goal of the establishment and organization of the "Foundation Livio Sciutto – NPO", an organization of which Prof. Grappiolo is the scientific director. Playing this role, Prof. Grappiolo has been creating and maintaining contacts with other national and international research institutes, which trained thousands of surgeons coming from every country of the world.

The organization has one of the largest hip replacement database of the world: more than 45.000. Dr. Grappiolo is mentored by Dr. Spotorno (a master and pioneer in prosthetic surgery), and their group studied and developed some of the bestselling prosthesis in the world. His research led him to contact the major international schools with which he collaborates in the search for new strategies of improvement in prosthetic minimally invasive and computer-assisted conservative surgery with the development of new prosthetic models and exploration of new materials.

To date, he has attended over 170 meetings, both national and international, almost every time in the role of speaker or chairman. His name appears as author, in more than 60 publications and articles. He has performed more than 2600 prosthetic surgery (hip, knee and ankle).

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=grappiolo

Dr. Giuseppe Marinari is a specialist in general surgery (1991) and nutrition (1995). He started his career in Bariatric Surgery in 1987 and, since then, he has performed over 7000 bariatric procedures, mainly Sleeve Gastrectomy, Gastric Bypass, and Biliopancreatic Diversion. Dr. Giuseppe Marinari has international experience, and he is one of the leading Bariatric surgeons in Italy. Over the past 10 years, he has focused on the implementation of a high-volume centre (>1250 procedures in 2019). Since 2016, he adopted an Enhanced Recovery After Bariatric Surgery (ERABS) protocol, to improve benefits for the patient. In essence, this means a faster recovery and an early return to daily activities, with a very high patient approval rating.

Obesity is a complex condition that encompasses a variety of comorbidities. Therefore, the role of a bariatric surgeon is multidisciplinary, including the understanding (and sometimes treating) of comorbidities as well as performing surgery.

Bariatrics interested Dr. Giuseppe Marinari at first because it was a new and growing field. He then developed an appreciation for the multidisciplinary aspect. Now Dr. Giuseppe Marinari is eager to help people transform their lives.

Dr. Giuseppe Marinari  was mentored by Prof. N. Scopinaro at the University Hospital in Genoa, Italy. He invented the biliopancreatic diversion (with or without duodenal switch), a malabsorptive bariatric operation. Dr. Marinari is now Director of the Bariatric Center. He has international experience and is one of the leading surgeons in his field. He performs both restrictive and malabsorbative bariatric procedures, mainly using the laparoscopic approach. In Humanitas Reasearch Hospital patients are treated by a multi-disciplinary team. The patients are given full attention and support throughout all the steps along the treatment.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=marinari+giuseppe

Dr. Federico Pessina is the Cranial Neurosurgey Unit Director.

Medical areas of interest: Brain tumors, glioblastomas, low grade gliomas, brain metastases, meningiomas, neuromas, cavernous angiomas, brain aneurysms

Surgical treatment with brain mapping techniques, awake and minimally invasive surgery of all central nervous system tumors.

Surgical treatment of highly complex tumors of the skull base and cranio-cervical hinge: meningiomas, neuromas, craniopharyngiomas, brain stem tumors.

All the tumor pathologies described above are addressed after multidisciplinary multi-specialist evaluation.

The surgical approach is customized to the patient and to the type of lesion, making use of the most advanced intraoperative techniques for malignant brain tumors (neuronavigation, intraoperative neurophysiology, intraoperative CT) and more complex approaches (anterior, posterior and combined petroosectomies, minimally invasive accesses) for benign diseases of the skull base such as meningiomas and neuromas.

Research areas of interest: Experimental protocols in the treatment of glioblastomas

- Prospective protocols in the treatment of brain metastases

- Role of surgical removal and integrated treatments in glioblastomas and malignant brain tumors

- Intracranial meningiomas

- Cadaver lab dissection

Author of more than 60 scientific publications and 5 book chapters, he is member of Italian Society of Neurosurgery (SINCH).

In 2018 he joined the Scientific Committee of European Society of Neuroncology (EANO) and the Skull Base Surgery Committee of World Federation of Neurosurgical Society (WFNS).

Specialized training: 

Prof. Pessina obtained his Degree in Medicine and Surgery in University of  Insubria,  Varese, where he also completed his Residency Program.

From 2007 to 2008 he covered the role of Clinical Fellow in Neurosurgery in Lausanne University Hospital, focusing on image-guided intrinsic brain tumors resection and vascular neurosurgery

In 2018 he covered the Skull Base fellow position in Lariboisiere Hospital, Paris, fully dedicating to skull base surgery and hands-on dissection practice and teaching.

Since 2022, he is Full Professor in Neurosurgery (MED/27) in Humanitas University

Additional information of interest:

Member of the Scientific Committee of the European Association of Neuroncology (EANO)

Publications:  https://www.ncbi.nlm.nih.gov/pubmed/?term=Pessina+Federico

Dr. Daniela Pini is the Head of the Cardio-respiratory rehabilitation Unit.

Medical areas of interest: Dr. Daniela Pini has been working and researching heart failure and has gained considerable experience in the management of advanced forms of this pathology. She is also very interested in the evaluation and "overall" management of patients suffering from this disease, which mainly affects elderly people and who already have other chronic diseases, which, if neglected, can easily impair the effectiveness of treatment for heart failure itself.

Research areas of interest: new therapies for advanced heart failure: replacement therapy of the heart with mechanical assistance devices to the circulation or heart transplant. New drugs and devices. Multidisciplinary patient management programs.

Further information of interest: thanks to the high competence of cardiosurgeons, electrophysiologists and hemodynamists, Humanitas can count, as a clinical cardiologist, on a team that allows it to offer the patient all the range of therapeutic options for heart failure.

From June 2000 to October 2001 she was Visiting Assistant Professor at the Cardiovascular Division Hospital of the University of Pennsylvania. During this period, she worked in the Heart Failure/Heart Transplantation Program, where she participated in the management of patients with advanced heart failure waiting for transplantation, dealing in particular with medical complications in patients with mechanical assistance devices. She has also worked with kidney, kidney-pancreas, pancreas-insulae, lung, liver and heart transplant teams, dealing with the multiple aspects of managing solid organ transplant recipients.

She worked in the Niguarda Ca' Granda Hospital, at the Cardiomyopathy and Heart Transplantation Service, dealing mainly with patients with advanced heart failure and undergoing a cardiac transplant.

Dr. Pini is a member of the coordination committee of the Decompensation Area of the National Association of Medical Hospital Cardiologists – ANMCO. In the last two years she has been mainly concerned on building a network of “heart failure clinics” on the national territory.

Prof. Eduardo Nobile Orazio is the Neurology Unit Director in Humanitas Research Hospital. 

His main areas of interest and specialisation are: diagnosis and treatment of neuromuscular diseases, in particular polyneuropathies, also including those of immunological origin such as Guillain Barré Syndrome (GBS) and the different clinical variants, chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN), and the polyneuropathies associated with monoclonal gammopathy, the neuropathies and paraneoplastic neuronopathies and neuropathies in the course of haematologic diseases and from chemotherapy. 

Immunological diagnosis of autoimmune diseases of the peripheral and central nervous system, diagnosis and treatment of motor neurone disease with suspected paraneoplastic or immune genesis, diagnosis and treatment of Multiple Sclerosis and other autoimmune and inflammatory diseases of the central nervous system such as autoimmune and paraneoplastic encephalitis, diagnosis and treatment of Parkinson’s Disease and extrapyramidal diseases.

His areas of research are clinical and immunological diagnosis and treatment of the immune mediated polyneuropathies and, in particular, GBS, CIDP, MMN and polyneuropathy associated with monoclonal gammopathy including POEMS.

Prof. Eduardo Nobile Orazio has written over 230 scientific publications, held more than 85 university seminars or conferences. He has been a member of the SIN since 1991, of the European Neurological Society since 1989 until 2014, when he joined the European Academy of Neurology. Prof. Eduardo Nobile Orazio has also been a member of the American Academy of Neurology since 1998 and of the American Neurological Association since 2012.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=Nobile-Or